The Associate Research Scientist position is available for a highly motivated candidate to work on a new DOE-funded project investigating the response to low doses of radiation in bone marrow stem cells, the target cell type for radiation-induced acute myeloid leukemia (AML). The project will leverage a 3-dimensional organoid model that reproduces key elements of the bone marrow niche to support the growth and function of human blood-forming stem cells, and will compare responses in bone marrow stem cells from healthy donors and donors with clonal hematopoiesis, a defined pre-leukemic condition that may sensitize individuals to radiation-induced leukemia. Endpoints will include changes in cell-type distribution, generation of reactive oxygen species, and both bulk and single-cell RNA-Seq analyses.
Our laboratory is in the Center for Radiological Research (crr.columbia.edu) in the Department of Radiation Oncology at Columbia University Irving Medical Center in Upper Manhattan, and the project is a collaboration with investigators in the Columbia Stem Cell Initiative (https://www.stemcell.columbia.edu). This is an outstanding opportunity to work with investigators in leading radiation biology and stem cell laboratories.
Minimum Degree Required
Ph.D. and/or M.D.
Minimum Qualifications
Candidates must have experience in molecular biology and cell culture, as well as excellent communication and writing skills. A background in stem cell biology, 3D organoids, radiation science, and/or cancer biology is also strongly preferred. At least three years of postdoc experience.
Columbia University is an Equal Opportunity Employer / Disability / Veteran
Pay Transparency Disclosure
The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training. The above hiring range represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting.
Equal Opportunity Employer / Disability / Veteran
Columbia University is committed to the hiring of qualified local residents.