Job description
Job Description
Vertex Pharmaceuticals is seeking a Contract Research Scientist to join the Chemical Biology group. We aim to treat serious diseases, many with targets difficult to drug. In this lab-based role, this scientist will help deploy novel covalent drug discovery techniques to the identification and validation of ligands for hard-to-target proteins. The ideal candidate is a motivated, detail oriented, life-long learner with expertise in covalent drug discovery and compound screening.
Key Duties and Responsibilities:
- High throughput compound screening
- Designing, executing and troubleshooting novel screening approaches for covalent ligand discovery
- Proactive verbal and written communication to effectively engage with scientists from different disciplines on the team.
- Collaboratively work with members of the team to coordinate screening staging and timing
Knowledge and Skills:
- Expertise in covalent chemoproteomics and data analysis
- Knowledgeable about concepts of compound binding affinity, selectivity, reactivity and kinetics
- Automation for liquid handling
- Affinity capture methods including immunoprecipitation
- Western analysis
- Cell biology (cell culture, lentiviral based expression)
Pay Range: dependent upon experience