We are partnering with a stealth-mode biotech startup in the San Francisco Bay Area that is pioneering biologics and cell therapy for oncology, cardiometabolic diseases, neurodegeneration, and inflammation. Backed by top-tier investors and led by world-class scientists, this company is integrating proteomics, synthetic biology, and AI-driven discovery to develop transformative therapies.
The Role
Our client is seeking a Head of Preclinical & Translational Research to lead the development and translational strategy for biologics and cell therapy programs across multiple therapeutic areas. This is a critical leadership role, working cross-functionally with discovery, clinical, and computational teams to advance novel therapies from early research through IND-enabling studies and first-in-human trials.
Key Responsibilities:
- Develop and execute preclinical and translational research strategies for biologics and cell therapy programs targeting oncology, cardiometabolic, neurodegenerative, and inflammatory diseases.
- Lead in vivo and in vitro pharmacology, mechanism-of-action studies, and biomarker discovery to inform clinical development.
- Oversee IND-enabling studies, ensuring robust preclinical packages for regulatory submissions.
- Establish and validate disease models and functional assays to assess efficacy, safety, and patient selection strategies.
- Build and mentor a high-performing translational research team, fostering a culture of scientific excellence and innovation.
- Work closely with clinical, regulatory, and bioinformatics teams to define translational strategies and biomarker-driven clinical approaches.
- Drive partnerships with CROs, academic collaborators, and industry partners to accelerate development timelines.
Qualifications:
- Ph.D., M.D., or equivalent in Immunology, Oncology, Cell Biology, Molecular Biology, or a related field, with 10+ years of industry experience.
- Proven track record in biologics and/or cell therapy development, with experience leading programs from discovery through IND submission.
- Deep expertise in immune-oncology, engineered cell therapies, antibody-based therapeutics, or gene-modified cell platforms.
- Strong understanding of disease mechanisms and translational approaches in oncology, cardiometabolic diseases, neurodegeneration, and inflammation.
- Leadership experience, with a history of building and managing cross-functional research teams.
- Experience in fast-paced biotech environments with a track record of driving programs to the clinic.
- Familiarity with regulatory requirements for IND submissions and early-stage clinical trial design.
The Benefits:
- Based in the Bay Area
- Competitive salary of $250-300,000 pa and extensive benefits package
- Progression opportunities – Chance to get on the ground floor with a well-funded and rapidly expanding Biotech
If you are looking to take the next step in your career in the Biotech industry and you would like to know more about this role or the other opportunities we currently have on our books, please apply now with your CV to speak with our specialist Scientific Consultant William Ashbrook